宋振远 医学生物化学与分子生物学 教授，博士生导师

Tel: 0571-86613724 

E-mail: song2008@uic.edu

一、个人简历（最终毕业院校、国内外进修访学经历、主要荣誉、主要社会兼职）：

宋振远，男，教授，博士生导师，毕业于美国阿肯色大学，营养生化专业博士。研究方向 代谢性肝病及代谢综合症的病理和分子机制。

浙江省首批“钱江学者”，浙江中医药大学大学特聘教授。长期从事代谢性肝病及代谢综合症的病因学研究，主持美国NIH基金3项，参加美国NIH基金3项。相应成果陆续发表在Hepatology, J Lipid Research，American Journal of Pathology，Biochemical Pharmacology，BBA等国际知名期刊。迄今为止，发表SCI文章近70篇（其中被国际肝脏病学著名期刊Hepatology收录5篇）。长期担任Gastroenterology，Hepatology，American Journal of Pathology，Endocrinology，Journal of Nutrition等SCI索引期刊审稿专家。

二、承担或参与科研、教学教改等项目情况（不超过10项）：

1. 4-HNE诱导的脂肪功能紊乱对酒精性脂肪肝发病作用的影响及机制研究(81470845)，国家自然科学基金项目,2014-08-25----2018-12-31,资助经费73 万元（负责人）

2. 反硝化细菌的鉴定及其与胆固醇降解相关蛋白、基因的初探,( 31600003), 国家自然科学基金项目, 2016-08-17------2019-12-31资助经费24 万元, （2/7）

三、学术成果奖励（不超过10项）：

四、国内外发明专利、新药证书等（不超过10项）：

五、代表性论文（不超过10篇）：

1. Shen C, Ma W, Ding L, Li S, Dou X, Song Z^#. The tlr4-ire1α pathway activation contributes to palmitate-elicited lipotoxicity in hepatocytes. Journal of Cellular\s&\smolecular Medicine. 2018.DOI: 10.1111/jcmm.13636

2. Dou X, Li S, Hu L, Ding L, Ma Y, Ma, W.Chai H, Song Z^#. Glutathione disulfide sensitizes hepatocytes to tnfα-mediated cytotoxicity via ikk-β s -glutathionylation: a potential mechanism underlying non-alcoholic fatty liver disease. Experimental & Molecular Medicine, 2018.50(4). DOI: 10.1038/s12276-017-0013-x

3. Li S, Dou X, Ning H, Song Q, Wei W, Zhang X, Li J, Sun X, Song Z^#. Sirt3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity. Hepatology, 2017.66(3), 936.

4. Li J, Dou X, Li S, Zhang X, Zeng Y, Song Z^#. Nicotinamide ameliorates palmitate-induced er stress in hepatocytes via camp/pka/creb pathway-dependent sirt1 upregulation. Biochim Biophys Acta. 2015.1853(11), 2929-2936. DOI: 10.1016/j.bbamcr.2015.09.003

5. Wang Z, Dou X, Li S, Zhang X, Sun X, Zhou Z, Song Z^#. Nuclear factor (erythroid-derived 2)-like 2 activation-induced hepatic very-low-density lipoprotein receptor overexpression in response to oxidative stress contributes to alcoholic liver disease in mice. Hepatology, 2014.59(4), 1381–1392. DOI: 10.1002/hep.26912

6. Dou X, Xia Y, Chen J, Qian Y, Li S, Zhang X, Song Z^#. Rectification of impaired adipose tissue methylation status and lipolytic response contributes to hepatoprotective effect of betaine in a mouse model of alcoholic liver disease. British Journal of Pharmacology, 2014. 171(17), 4073-4086. DOI: 10.1111/bph.12765

7. Li S, Li J., Shen C, Zhang X, Sun S, Cho M, Sun X, Song Z^#. Tert-butylhydroquinone (tbhq) protects hepatocytes against lipotoxicity via inducing autophagy independently of nrf2 activation. Biochim Biophys Acta, 2014,1841(1), 22-33. DOI: 10.1016/j.bbalip.2013.09.004

8. Dou X, Chen S, Wang Z, Li S, Zhang X, Song Z^#. Protection of nicotinic acid against oxidative stress-induced cell death in hepatocytes contributes to its beneficial effect on alcohol-induced liver injury in mice. Journal of Nutritional Biochemistry, 2013.24(8), 1520-1528.

9, Gu D, Wang Z, Dou X, Zhang X, Li S, Vu L, Yao T, Song Z^#. Inhibition of erk1/2 pathway suppresses adiponectin secretion via accelerating protein degradation by ubiquitin-proteasome system: relevance to obesity-related adiponectin decline. Metabolism-clinical & Experimental, 2013.62(8), 1137-1148. DOI: 10.1016/j.metabol.2013.01.025

10. Zhang X, Wang Z, Li J., Gu D, Li S, Shen C, Song Z^#. Increased 4-hydroxynonenal formation contributes to obesity-related lipolytic activation in adipocytes. Plos One, 2013. 8(8), e70663. DOI: 10.1371/journal.pone.0070663

六、代表性著作