2025-06-23 点击:[]
国家自然科学基金委员会监督委员会对江苏某高校徐泽宽等发表的论文涉嫌学术不端开展了调查。涉及论文如下:
论文1:Zekuan Xu*, et al. miR‐664a‐3p functions as an oncogene by targeting Hippo pathway in the development of gastric cancer. Cell Proliferation, 2019, 52(3): e12567.(标注基金号81572362、81361120398)
论文2:Zekuan Xu*, et al. Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway. Molecular Cancer, 2019, 18(1): 20.(标注基金号81572362、81361120398)
论文3:Zekuan Xu*, et al. Circular RNA UBE2Q2 promotes malignant progression of gastric cancer by regulating signal transducer and activator of transcription 3-mediated autophagy and glycolysis. Cell Death and Disease, 2021, 12(10): 910.(标注基金号81871946、82072708)
论文4:Zekuan Xu*, et al. Novel role of miR-133a-3p in repressing gastric cancer growth and metastasis via blocking autophagy-mediated glutaminolysis. Journal of Experimental & Clinical Cancer, 2018, 37(1): 320.(标注基金号81572362、81361120398)
论文5:Zekuan Xu*, et al. ZNF143 enhances metastasis of gastric cancer by promoting the process of EMT through PI3K/AKT signaling pathway. Tumor Biology, 2016, 37(9): 12813-12821.(标注基金号81272712、81572362、812111519)
论文6:Zekuan Xu*, et al. miR-3174 Contributes to Apoptosis and Autophagic Cell Death Defects in Gastric Cancer Cells by Targeting ARHGAP10. Molecular Therapy: Nucleic Acids, 2017, 9: 294-311.(标注基金号81361120398、81572362)
论文7:Zekuan Xu*, et al. Overexpression of miR-584-5p inhibits proliferation and induces apoptosis by targeting WW domain-containing E3 ubiquitin protein ligase 1 in gastric cancer. Journal of Experimental & Clinical Cancer Research, 2017, 36(1): 59.(标注基金号81361120398、81572362)
论文8:Zekuan Xu*, et al. Netrin-1 promotes gastric cancer cell proliferation and invasion via the receptor neogenin through PI3K/AKT signaling pathway. Oncotarget, 2017, 8(31): 51177-51189. (标注基金号81572362、81602080、812111519)
论文9:Zekuan Xu*, et al. MiR-422a regulates cellular metabolism and malignancy by targeting pyruvate dehydrogenase kinase 2 in gastric cancer. Cell Death & Disease, 2018, 9(5): 505.(标注基金号81572362、81361120398)
论文10:Zekuan Xu*, et al. miR-874 functions as a tumor suppressor by inhibiting angiogenesis through STAT3/VEGF-A pathway in gastric cancer. Oncotarget, 2015, 6(3): 1605-17.(标注基金号81361120398、81272712、30901421)
经查,10篇涉事论文多幅图片相同但代表不同含义,存在图片虚假的客观结果。10篇论文的通讯作者徐泽宽等人应对论文存在的问题负责。
此外,徐泽宽将论文1至论文3、论文5至论文8、论文10分别列入相关基金项目(批准号81572362、81871946、81361120398)申请书或进展报告、结题报告。徐泽宽还应对此问题负责。
经国家自然科学基金委员会监督委员会六届五次会议审议,由国家自然科学基金委员会2024年第20次委务会议审定,决定依据《国家自然科学基金项目科研不端行为调查处理办法》第四十七条、第四十条、第四十六条,撤销徐泽宽国家自然科学基金项目“幽门螺旋杆菌通过促进BRD2m6A修饰打破FLIP/Caspase-8稳态增强胃癌细胞化疗敏感性的机制研究”(批准号82072708)、“胃癌细胞来源外泌体miR-519a-3p通过抑制肝Kupffer细胞Lefty1分泌以促进肝转移灶形成的机制研究”(批准号81871946)、“慢性应激在胃癌发生过程中的作用及机制研究”(批准号81572362)、“MUC4独有结构域NIDO、AMOP及vWD在胰腺癌特征性肿瘤学行为中的作用及机制研究”(批准号81272712)和“异常表达微小RNA对胃癌发生发展过程的调控研究”(批准号81361120398),追回上述5个项目的已拨资金,取消徐泽宽国家自然科学基金项目申请和参与申请资格3年(2024年12月10日至2027年12月9日),给予徐泽宽通报批评。